Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC009
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-07-14 14:55
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment Madopar 250mg 3x 1/4; Mirapexin 2,1mg 1x1; Rivotril 2mg 1x1/4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 20 individuals with a value less than 0.58 were subsequently diagnosed with PD. That is, 47.62% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.58 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 12, 'TN': 11, 'TP': 30, 'FP': 19}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 12, 'TN': 11, 'TP': 30, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 14, 'TN': 8, 'TP': 28, 'FP': 22}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 5, 'TP': 33, 'FP': 25}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 6.444
timePerCircleCoV 0.212675
timePerCircleSlope -0.0623366
meanError 1.9323
tremorFreq 6.25
tremorRelPower 60.7547
tremorGyroAmpMean 0.0640524
tremorGyroAmpSlope -0.00456087
tremorGyroAmpCoV 0.352424
tremorCoordAmpMean 0.0972644
tremorCoordAmpSlope -0.00519458
tremorCoordAmpCoV 0.391799
tremorAccAmpMean 0.11571
tremorAccAmpSlope -0.00286485
tremorAccAmpCoV 0.244203
tremorPcRelVar 0.765112
tremorPcX -0.442694
tremorPcY -0.896673

Circle Segment 1

Duration 8.24 s, Accuracy Estimate 2.28 (lower is better)

Circle Segment 2

Duration 7.8 s, Accuracy Estimate 2.048 (lower is better)

Circle Segment 3

Duration 6.8 s, Accuracy Estimate 1.775 (lower is better)

Circle Segment 4

Duration 6.52 s, Accuracy Estimate 1.538 (lower is better)

Circle Segment 5

Duration 7.08 s, Accuracy Estimate 1.662 (lower is better)

Circle Segment 6

Duration 6.8 s, Accuracy Estimate 1.782 (lower is better)

Circle Segment 7

Duration 6.92 s, Accuracy Estimate 1.936 (lower is better)

Circle Segment 8

Duration 5.92 s, Accuracy Estimate 1.674 (lower is better)

Circle Segment 9

Duration 4.64 s, Accuracy Estimate 1.741 (lower is better)

Circle Segment 10

Duration 3.72 s, Accuracy Estimate 2.886 (lower is better)

Spiral

numSpirals 11
timePerSpiralMean 17.1273
timePerSpiralCoV 0.172943
timePerSpiralSlope 0.0204883
meanError 1.92512
tremorFreq 6.25
tremorRelPower 43.5611
tremorGyroAmpMean 0.049468
tremorGyroAmpSlope -0.00381613
tremorGyroAmpCoV 0.382429
tremorCoordAmpMean 0.0957879
tremorCoordAmpSlope -0.00282385
tremorCoordAmpCoV 0.340375
tremorAccAmpMean 0.106871
tremorAccAmpSlope -0.00173387
tremorAccAmpCoV 0.20441
tremorPcRelVar 0.67761
tremorPcX 0.393166
tremorPcY 0.919468

Spiral Segment 1

Duration 17.08 s, Accuracy Estimate 2.251 (lower is better)

Spiral Segment 2

Duration 15.24 s, Accuracy Estimate 2.228 (lower is better)

Spiral Segment 3

Duration 15.44 s, Accuracy Estimate 2.59 (lower is better)

Spiral Segment 4

Duration 14.32 s, Accuracy Estimate 1.939 (lower is better)

Spiral Segment 5

Duration 13.0 s, Accuracy Estimate 1.704 (lower is better)

Spiral Segment 6

Duration 23.88 s, Accuracy Estimate 1.58 (lower is better)

Spiral Segment 7

Duration 17.0 s, Accuracy Estimate 2.039 (lower is better)

Spiral Segment 8

Duration 16.08 s, Accuracy Estimate 1.779 (lower is better)

Spiral Segment 9

Duration 19.56 s, Accuracy Estimate 1.706 (lower is better)

Spiral Segment 10

Duration 18.92 s, Accuracy Estimate 1.686 (lower is better)

Spiral Segment 11

Duration 17.88 s, Accuracy Estimate 1.676 (lower is better)

Elel

eDurationMean 0.594556
eDurationStd 0.149476
eDurationStdnorm 0.251407
eDurationMedian 0.56
eDurationQuartdelta 0.19375
eDurationQuartdeltanorm 0.345982
eDurationKurt 4.37394
eDurationTrenddiff -0.1975
eDurationTrendratio 0.710623
eWidthMean 5.3924
eWidthStd 1.20867
eWidthStdnorm 0.224143
eWidthMedian 5.148
eWidthQuartdelta 1.55025
eWidthQuartdeltanorm 0.301136
eWidthKurt 2.94366
eWidthTrenddiff -0.7605
eWidthTrendratio 0.863158
eHeightMean 11.401
eHeightStd 2.52464
eHeightStdnorm 0.22144
eHeightMedian 10.413
eHeightQuartdelta 3.393
eHeightQuartdeltanorm 0.325843
eHeightKurt 3.0951
eHeightTrenddiff -3.276
eHeightTrendratio 0.743119
eAspectMean 0.480663
eAspectStd 0.0905924
eAspectStdnorm 0.188474
eAspectMedian 0.471698
eAspectQuartdelta 0.109839
eAspectQuartdeltanorm 0.232859
eAspectKurt 2.56987
eAspectTrenddiff 0.0643327
eAspectTrendratio 1.14374
eSlantMean -0.108818
eSlantStd 0.217783
eSlantStdnorm -2.00135
eSlantMedian -0.0873786
eSlantQuartdelta 0.272562
eSlantQuartdeltanorm -3.11933
eSlantKurt 2.66294
eSlantTrenddiff 0.0877786
eRtopMean 0.645339
eRtopStd 0.169413
eRtopStdnorm 0.262517
eRtopMedian 0.645161
eRtopQuartdelta 0.23951
eRtopQuartdeltanorm 0.37124
eRtopKurt 4.80892
eRtopTrenddiff 0.0594986
eRbotMean 0.882066
eRbotStd 0.330413
eRbotStdnorm 0.37459
eRbotMedian 0.870968
eRbotQuartdelta 0.402272
eRbotQuartdeltanorm 0.461868
eRbotKurt 3.41656
eRbotTrenddiff -0.032324
eRrightMean 0.771168
eRrightStd 0.105335
eRrightStdnorm 0.136591
eRrightMedian 0.766234
eRrightQuartdelta 0.126718
eRrightQuartdeltanorm 0.165378
eRrightKurt 3.75663
eRrightTrenddiff 0.0257413
eRleftMean 0.492674
eRleftStd 0.169697
eRleftStdnorm 0.344442
eRleftMedian 0.487395
eRleftQuartdelta 0.22233
eRleftQuartdeltanorm 0.45616
eRleftKurt 3.05088
eRleftTrenddiff -0.0259497
lDurationMean 0.687727
lDurationStd 0.142704
lDurationStdnorm 0.207501
lDurationMedian 0.6675
lDurationQuartdelta 0.155
lDurationQuartdeltanorm 0.23221
lDurationKurt 7.47204
lDurationTrenddiff -0.1
lDurationTrendratio 0.86014
lWidthMean 9.38393
lWidthStd 2.3485
lWidthStdnorm 0.250268
lWidthMedian 8.9505
lWidthQuartdelta 3.6855
lWidthQuartdeltanorm 0.411765
lWidthKurt 2.37541
lWidthTrenddiff -2.106
lWidthTrendratio 0.8
lHeightMean 24.9768
lHeightStd 4.40178
lHeightStdnorm 0.176234
lHeightMedian 24.921
lHeightQuartdelta 5.148
lHeightQuartdeltanorm 0.206573
lHeightKurt 3.51105
lHeightTrenddiff -4.3875
lHeightTrendratio 0.83871
lAspectMean 0.380691
lAspectStd 0.0884932
lAspectStdnorm 0.232454
lAspectMedian 0.376561
lAspectQuartdelta 0.121984
lAspectQuartdeltanorm 0.323942
lAspectKurt 2.54683
lAspectTrenddiff -0.00494395
lAspectTrendratio 0.987041
lSlantMean 0.0403141
lSlantStd 0.155185
lSlantStdnorm 3.8494
lSlantMedian 0.0363186
lSlantQuartdelta 0.21799
lSlantQuartdeltanorm 6.00214
lSlantKurt 2.92198
lSlantTrenddiff 0.0566877
lRtopMean 0.696339
lRtopStd 0.157988
lRtopStdnorm 0.226884
lRtopMedian 0.716693
lRtopQuartdelta 0.215219
lRtopQuartdeltanorm 0.300294
lRtopKurt 4.18818
lRtopTrenddiff -0.00319552
lRbotMean 0.653544
lRbotStd 0.286791
lRbotStdnorm 0.438824
lRbotMedian 0.623527
lRbotQuartdelta 0.368361
lRbotQuartdeltanorm 0.59077
lRbotKurt 2.67107
lRbotTrenddiff -0.0904973
lRrightMean 0.818435
lRrightStd 0.0951136
lRrightStdnorm 0.116214
lRrightMedian 0.833742
lRrightQuartdelta 0.110247
lRrightQuartdeltanorm 0.132231
lRrightKurt 4.9568
lRrightTrenddiff -0.00409506
lRleftMean 0.398134
lRleftStd 0.178765
lRleftStdnorm 0.449007
lRleftMedian 0.37122
lRleftQuartdelta 0.272389
lRleftQuartdeltanorm 0.733768
lRleftKurt 2.53787
lRleftTrenddiff -0.023456

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.865553
sumTouchScores 15.58
meanMovementTime 0.797647
numTouches 18
undershootPercentage 0
overshootPercentage 5.55556

FITTS Long Modified

meanTouchScore 0.745413
sumTouchScores 14.1628
meanMovementTime 0.987222
numTouches 19
undershootPercentage 5.26316
overshootPercentage 5.26316

ZigZag

numZigzags 5
timePerZigzagMean 13.336
timePerZigzagCoV 0.0570123
timePerZigzagSlope -0.0359928
meanError 2.53434
tremorFreq 6.25
tremorRelPower 49.2202
tremorGyroAmpMean 0.085378
tremorGyroAmpSlope -0.000723335
tremorGyroAmpCoV 0.459885
tremorCoordAmpMean 0.144707
tremorCoordAmpSlope -0.000554974
tremorCoordAmpCoV 0.321937
tremorAccAmpMean 0.144881
tremorAccAmpSlope -0.000698419
tremorAccAmpCoV 0.252826
tremorPcRelVar 0.735116
tremorPcX -0.258088
tremorPcY 0.966121

ZigZag Segment 1

Duration 14.24 s, Accuracy Estimate 2.233 (lower is better)

ZigZag Segment 2

Duration 13.88 s, Accuracy Estimate 2.201 (lower is better)

ZigZag Segment 3

Duration 13.36 s, Accuracy Estimate 2.567 (lower is better)

ZigZag Segment 4

Duration 12.84 s, Accuracy Estimate 2.659 (lower is better)

ZigZag Segment 5

Duration 12.36 s, Accuracy Estimate 3.011 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 12.128
timePerZigzagCoV 0.161566
timePerZigzagSlope -0.0913588
zigzagHeightMean 57.5981
zigzagHeightCoV 0.0530457
zigzagHeightSlope 0.020428
meanError 0.0405026
tremorFreq 6.15234
tremorRelPower 46.9018
tremorGyroAmpMean 0.0832059
tremorGyroAmpSlope 2.84724e-05
tremorGyroAmpCoV 0.431266
tremorCoordAmpMean 0.15311
tremorCoordAmpSlope -0.00283769
tremorCoordAmpCoV 0.348016
tremorAccAmpMean 0.143839
tremorAccAmpSlope -0.00368196
tremorAccAmpCoV 0.284862
tremorPcRelVar 0.680706
tremorPcX 0.132622
tremorPcY -0.991167

ZigZag Offset Segment 1

Duration 15.44 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 2

Duration 12.16 s, Accuracy Estimate 0.042 (lower is better)

ZigZag Offset Segment 3

Duration 11.44 s, Accuracy Estimate 0.03 (lower is better)

ZigZag Offset Segment 4

Duration 11.24 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 5

Duration 10.36 s, Accuracy Estimate 0.071 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.71}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.58}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.4605191750538895}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9231483135518013}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6635103089489831}